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Can a Progressive Disease Improve without treatment?
Data scientist in Basel
3283
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Topic

Multiple Sclerosis

Sometimes the severity of progressive multiple sclerosis improves naturally, and we know little about this.

Setup

Rewoso

Part of rewoso‘s real-world data science for industry

Design

R

Realized in R-Statistics, SQL

Natural Improvements of Disease Severity in Multiple Sclerosis

We examined if the symptoms of progressive multiple sclerosis can improve reliably and clinically meaningfully even if not treated.

After selecting patients with progressive multiple sclerosis who received no treatment and had no relapses in two years, we classified patients as experiencing disease improvements. Disease improvements were defined based on the expanded disability scale by a clinically meaningful improvement from baseline which needed to be lasting for 6 months or longer, measuring confirmed disability improvements. The results showed that indeed there was a minority (< 5%) of untreated progressive multiple sclerosis patients with spontaneous meaningful and lasting disease improvements.

You can read the abstract and view the poster after the ACTRIMS 24 homepage was updated.